Vishwa Deep Dixit, DVM, PhD
Waldemar Von Zedtwitz Professor of Pathology and Professor of Immunobiology; Director, Yale Center for Research on Aging (Y-Age), Pathology
Research & Publications
Biography
News
Research Summary
A major goal of Dixit lab is to obtain creative insights that advance knowledge in the field of Immune-Metabolic interactions that drive adiposity and age-related chronic diseases. Studies focus on understanding the mechanisms and consequences of aberrant immune-cell activation in adipose tissue microenvironment and age-related ectopic adipocyte development in lymphoid microenvironment like thymus and bone marrow. The long-term goal of Dixit lab is to understand the mechanisms of immune-metabolic crosstalk and to help develop novel approaches to regulate the aberrant immune cell activation and inflammation as means to enhance healthspan and lifespan.
Extensive Research Description
Dixit’s research is focused on Immunometabolism with the goal to reveal molecular targets that can be harnessed to enhance healthspan with longevity. His laboratory found that pro-longevity hormone FGF21 protects against thymic degeneration and T cell senescence during aging. The ongoing work on this project utilizes various genetic and pharmacological approaches to regulate FGF21 signaling and determine its mechanism of action in control of age-related inflammation and immune-senescence.
Dixit lab has identified a specialized macrophage subset called the Nerve-associated macrophages (NAMs) that resides on sympathetic nerves and controls the bioavailability of catecholamines in tissue microenvironments. The identity of NAMs their function and role in health and disease are unclear and are a major focus of his lab.
Dixit and collaborators help define the role of innate immune sensor NLRP3 inflammasome in age-related chronic diseases, insulin-resistance, type 2 diabetes and immune-senescence and development of inflammation. His lab has also identified that ketone metabolite β-hydroxybutyrate (BHB) is a therapeutic target to lower the NLRP3 inflammasome -dependent chronic inflammatory diseases. The ongoing work in Dixitlab is investigating metabolic regulators of inflammasome deactivation and mechanism of age-related inflammation as a trigger for chronic disease.
The Dixit lab uses reverse translation approach, where his group has established the impact of caloric restriction (CR) on human physiology and immunometabolism (CALERIE-II trial) and are using animal models to test causality to develop CR-mimetic targets that could potentially confer pro-longevity benefits of CR. This work led to identification of PLA2G7 and SPARC as CR-inhibited proteins in humans that control inflammaging and healthspan.
The research in Dixit Lab is funded by the National Institutes of Health and Cure Alzheimer Fund.
Coauthors
Public Health Interests
Aging; Immunology; Obesity
Research Image
dixit-intro
Selected Publications
- When a calorie is not just a calorie: Diet quality and timing as mediators of metabolism and healthy agingMihaylova M, Chaix A, Delibegovic M, Ramsey J, Bass J, Melkani G, Singh R, Chen Z, Ja W, Shirasu-Hiza M, Latimer M, Mattison J, Thalacker-Mercer A, Dixit V, Panda S, Lamming D. When a calorie is not just a calorie: Diet quality and timing as mediators of metabolism and healthy aging. Cell Metabolism 2023, 35: 1114-1131. PMID: 37392742, PMCID: PMC10528391, DOI: 10.1016/j.cmet.2023.06.008.
- Innate immune cell-intrinsic ketogenesis is dispensable for organismal metabolism and age-related inflammationGoldberg E, Letian A, Dlugos T, Leveau C, Dixit V. Innate immune cell-intrinsic ketogenesis is dispensable for organismal metabolism and age-related inflammation. Journal Of Biological Chemistry 2023, 299: 103005. PMID: 36775129, PMCID: PMC10025153, DOI: 10.1016/j.jbc.2023.103005.
- Unified total synthesis of the limonoid alkaloids: Strategies for the de novo synthesis of highly substituted pyridine scaffoldsSchuppe A, Liu Y, Gonzalez-Hurtado E, Zhao Y, Jiang X, Ibarraran S, Huang D, Wang E, Lee J, Loria J, Dixit V, Li X, Newhouse T. Unified total synthesis of the limonoid alkaloids: Strategies for the de novo synthesis of highly substituted pyridine scaffolds. Chem 2022, 8: 2856-2887. PMID: 37396824, PMCID: PMC10311986, DOI: 10.1016/j.chempr.2022.09.012.
- The matricellular protein SPARC induces inflammatory interferon-response in macrophages during agingRyu S, Sidorov S, Ravussin E, Artyomov M, Iwasaki A, Wang A, Dixit VD. The matricellular protein SPARC induces inflammatory interferon-response in macrophages during aging. Immunity 2022, 55: 1609-1626.e7. PMID: 35963236, PMCID: PMC9474643, DOI: 10.1016/j.immuni.2022.07.007.
- Immune cells use hunger hormones to aid healingDixit VD. Immune cells use hunger hormones to aid healing. Nature 2022, 609: 39-40. PMID: 35948678, DOI: 10.1038/d41586-022-02105-z.
- Caloric restriction in humans reveals immunometabolic regulators of health spanSpadaro O, Youm Y, Shchukina I, Ryu S, Sidorov S, Ravussin A, Nguyen K, Aladyeva E, Predeus AN, Smith SR, Ravussin E, Galban C, Artyomov MN, Dixit VD. Caloric restriction in humans reveals immunometabolic regulators of health span. Science 2022, 375: 671-677. PMID: 35143297, PMCID: PMC10061495, DOI: 10.1126/science.abg7292.
- IL-27 signalling promotes adipocyte thermogenesis and energy expenditureWang Q, Li D, Cao G, Shi Q, Zhu J, Zhang M, Cheng H, Wen Q, Xu H, Zhu L, Zhang H, Perry RJ, Spadaro O, Yang Y, He S, Chen Y, Wang B, Li G, Liu Z, Yang C, Wu X, Zhou L, Zhou Q, Ju Z, Lu H, Xin Y, Yang X, Wang C, Liu Y, Shulman GI, Dixit VD, Lu L, Yang H, Flavell RA, Yin Z. IL-27 signalling promotes adipocyte thermogenesis and energy expenditure. Nature 2021, 600: 314-318. PMID: 34819664, DOI: 10.1038/s41586-021-04127-5.
- Desmosterol suppresses macrophage inflammasome activation and protects against vascular inflammation and atherosclerosisZhang X, McDonald JG, Aryal B, Canfrán-Duque A, Goldberg EL, Araldi E, Ding W, Fan Y, Thompson BM, Singh AK, Li Q, Tellides G, Ordovás-Montanes J, García Milian R, Dixit VD, Ikonen E, Suárez Y, Fernández-Hernando C. Desmosterol suppresses macrophage inflammasome activation and protects against vascular inflammation and atherosclerosis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2107682118. PMID: 34782454, PMCID: PMC8617522, DOI: 10.1073/pnas.2107682118.
- IL-33 causes thermogenic failure in aging by expanding dysfunctional adipose ILC2Goldberg EL, Shchukina I, Youm YH, Ryu S, Tsusaka T, Young KC, Camell CD, Dlugos T, Artyomov MN, Dixit VD. IL-33 causes thermogenic failure in aging by expanding dysfunctional adipose ILC2. Cell Metabolism 2021, 33: 2277-2287.e5. PMID: 34473956, PMCID: PMC9067336, DOI: 10.1016/j.cmet.2021.08.004.
- Ketogenic diet restrains aging-induced exacerbation of coronavirus infection in miceRyu S, Shchukina I, Youm YH, Qing H, Hilliard B, Dlugos T, Zhang X, Yasumoto Y, Booth CJ, Fernández-Hernando C, Suárez Y, Khanna K, Horvath TL, Dietrich MO, Artyomov M, Wang A, Dixit VD. Ketogenic diet restrains aging-induced exacerbation of coronavirus infection in mice. ELife 2021, 10: e66522. PMID: 34151773, PMCID: PMC8245129, DOI: 10.7554/elife.66522.
- Adiponectin preserves metabolic fitness during agingLi N, Zhao S, Zhang Z, Zhu Y, Gliniak CM, Vishvanath L, An YA, Wang MY, Deng Y, Zhu Q, Shan B, Sherwood A, Onodera T, Oz OK, Gordillo R, Gupta RK, Liu M, Horvath TL, Dixit VD, Scherer PE. Adiponectin preserves metabolic fitness during aging. ELife 2021, 10: e65108. PMID: 33904399, PMCID: PMC8099426, DOI: 10.7554/elife.65108.
- Enhanced epigenetic profiling of classical human monocytes reveals a specific signature of healthy aging in the DNA methylomeShchukina I, Bagaitkar J, Shpynov O, Loginicheva E, Porter S, Mogilenko DA, Wolin E, Collins P, Demidov G, Artomov M, Zaitsev K, Sidorov S, Camell C, Bambouskova M, Arthur L, Swain A, Panteleeva A, Dievskii A, Kurbatsky E, Tsurinov P, Chernyatchik R, Dixit VD, Jovanovic M, Stewart SA, Daly MJ, Dmitriev S, Oltz EM, Artyomov MN. Enhanced epigenetic profiling of classical human monocytes reveals a specific signature of healthy aging in the DNA methylome. Nature Aging 2020, 1: 124-141. PMID: 34796338, PMCID: PMC8597198, DOI: 10.1038/s43587-020-00002-6.
- Dietary Regulation of ImmunityLee AH, Dixit VD. Dietary Regulation of Immunity. Immunity 2020, 53: 510-523. PMID: 32937152, PMCID: PMC7491384, DOI: 10.1016/j.immuni.2020.08.013.
- Ketogenesis activates metabolically protective γδ T cells in visceral adipose tissueGoldberg EL, Shchukina I, Asher JL, Sidorov S, Artyomov MN, Dixit VD. Ketogenesis activates metabolically protective γδ T cells in visceral adipose tissue. Nature Metabolism 2020, 2: 50-61. PMID: 32694683, PMCID: PMC10150608, DOI: 10.1038/s42255-019-0160-6.
- Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic HomeostasisCamell CD, Günther P, Lee A, Goldberg EL, Spadaro O, Youm YH, Bartke A, Hubbard GB, Ikeno Y, Ruddle NH, Schultze J, Dixit VD. Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis. Cell Metabolism 2019, 30: 1024-1039.e6. PMID: 31735593, PMCID: PMC6944439, DOI: 10.1016/j.cmet.2019.10.006.
- AGING INDUCES NLRP3 INFLAMMASOME DEPENDENT ADIPOSE B CELL EXPANSION TO IMPAIR METABOLIC HOMEOSTASISCamell C, Dixit V. AGING INDUCES NLRP3 INFLAMMASOME DEPENDENT ADIPOSE B CELL EXPANSION TO IMPAIR METABOLIC HOMEOSTASIS. Innovation In Aging 2019, 3: s106-s106. PMCID: PMC6845598, DOI: 10.1093/geroni/igz038.397.
- Ketogenic diet activates protective γδ T cell responses against influenza virus infectionGoldberg EL, Molony RD, Kudo E, Sidorov S, Kong Y, Dixit VD, Iwasaki A. Ketogenic diet activates protective γδ T cell responses against influenza virus infection. Science Immunology 2019, 4 PMID: 31732517, PMCID: PMC7189564, DOI: 10.1126/sciimmunol.aav2026.
- Bone Marrow: An Immunometabolic Refuge during Energy DepletionGoldberg EL, Dixit VD. Bone Marrow: An Immunometabolic Refuge during Energy Depletion. Cell Metabolism 2019, 30: 621-623. PMID: 31577929, DOI: 10.1016/j.cmet.2019.08.022.
- Anti‐inflammatory effects of oestrogen mediate the sexual dimorphic response to lipid‐induced insulin resistanceCamporez JP, Lyu K, Goldberg EL, Zhang D, Cline GW, Jurczak MJ, Dixit VD, Petersen KF, Shulman GI. Anti‐inflammatory effects of oestrogen mediate the sexual dimorphic response to lipid‐induced insulin resistance. The Journal Of Physiology 2019, 597: 3885-3903. PMID: 31206703, PMCID: PMC6876753, DOI: 10.1113/jp277270.
- Ketogenic diet activates protective γδ T cell responses against influenza virus infectionGoldberg E, Molony R, Sidorov S, Kudo E, Dixit V, Iwasaki A. Ketogenic diet activates protective γδ T cell responses against influenza virus infection. The Journal Of Immunology 2019, 202: 62.7-62.7. DOI: 10.4049/jimmunol.202.supp.62.7.
- SUN-097 AgRP Neurons Determine Survival in Activity-Based Anorexia ModelMiletta M, Shanabrough M, Sestan-Pesa M, Varela L, Mancini G, Spadaro O, Zeiss C, Dixit V, Dietrich M, Horvath T. SUN-097 AgRP Neurons Determine Survival in Activity-Based Anorexia Model. Journal Of The Endocrine Society 2019, 3: sun-097. PMCID: PMC6553392, DOI: 10.1210/js.2019-sun-097.
- NLRP3 Inflammasome regulation of lipolysis in aged adipose tissueCamell C, Dixit V. NLRP3 Inflammasome regulation of lipolysis in aged adipose tissue. The FASEB Journal 2019, 33: 78.2-78.2. DOI: 10.1096/fasebj.2019.33.1_supplement.78.2.
- Gaining Weight: Insulin-Eating Islet MacrophagesSpadaro O, Dixit VD. Gaining Weight: Insulin-Eating Islet Macrophages. Immunity 2019, 50: 13-15. PMID: 30650372, DOI: 10.1016/j.immuni.2018.12.026.
- Loss of Nucleobindin-2 Causes Insulin Resistance in Obesity without Impacting Satiety or AdiposityRavussin A, Youm YH, Sander J, Ryu S, Nguyen K, Varela L, Shulman GI, Sidorov S, Horvath TL, Schultze JL, Dixit VD. Loss of Nucleobindin-2 Causes Insulin Resistance in Obesity without Impacting Satiety or Adiposity. Cell Reports 2018, 24: 1085-1092.e6. PMID: 30067966, PMCID: PMC6223120, DOI: 10.1016/j.celrep.2018.06.112.
- Pathogenesis of hypothyroidism-induced NAFLD is driven by intra- and extrahepatic mechanismsFerrandino G, Kaspari RR, Spadaro O, Reyna-Neyra A, Perry RJ, Cardone R, Kibbey RG, Shulman GI, Dixit VD, Carrasco N. Pathogenesis of hypothyroidism-induced NAFLD is driven by intra- and extrahepatic mechanisms. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: e9172-e9180. PMID: 29073114, PMCID: PMC5664516, DOI: 10.1073/pnas.1707797114.
- Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageingCamell CD, Sander J, Spadaro O, Lee A, Nguyen KY, Wing A, Goldberg EL, Youm YH, Brown CW, Elsworth J, Rodeheffer MS, Schultze JL, Dixit VD. Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing. Nature 2017, 550: 119-123. PMID: 28953873, PMCID: PMC5718149, DOI: 10.1038/nature24022.
- Energy Sparing Orexigenic Inflammation of ObesityLee A, Dixit VD. Energy Sparing Orexigenic Inflammation of Obesity. Cell Metabolism 2017, 26: 10-12. PMID: 28683278, DOI: 10.1016/j.cmet.2017.06.013.
- NLRP3 Inflammasome controls adipose tissue macrophage activation during agingCamell C, Sander J, Spadaro O, Lee A, Nguyen K, Wing A, Goldberg E, Youm Y, Rodeheffer M, Schultze J, Dixit V. NLRP3 Inflammasome controls adipose tissue macrophage activation during aging. The Journal Of Immunology 2017, 198: 154.3-154.3. DOI: 10.4049/jimmunol.198.supp.154.3.
- IGF1 Shapes Macrophage Activation in Response to Immunometabolic ChallengeSpadaro O, Camell CD, Bosurgi L, Nguyen KY, Youm YH, Rothlin CV, Dixit VD. IGF1 Shapes Macrophage Activation in Response to Immunometabolic Challenge. Cell Reports 2017, 19: 225-234. PMID: 28402847, PMCID: PMC5513500, DOI: 10.1016/j.celrep.2017.03.046.
- β-Hydroxybutyrate Deactivates Neutrophil NLRP3 Inflammasome to Relieve Gout FlaresGoldberg EL, Asher JL, Molony RD, Shaw AC, Zeiss CJ, Wang C, Morozova-Roche LA, Herzog RI, Iwasaki A, Dixit VD. β-Hydroxybutyrate Deactivates Neutrophil NLRP3 Inflammasome to Relieve Gout Flares. Cell Reports 2017, 18: 2077-2087. PMID: 28249154, PMCID: PMC5527297, DOI: 10.1016/j.celrep.2017.02.004.
- Carnitine acetyltransferase (CRAT) expression in macrophages is dispensable for nutrient stress sensing and inflammationGoldberg EL, Dixit VD. Carnitine acetyltransferase (CRAT) expression in macrophages is dispensable for nutrient stress sensing and inflammation. Molecular Metabolism 2017, 6: 219-225. PMID: 28180063, PMCID: PMC5279934, DOI: 10.1016/j.molmet.2016.12.008.
- Growth Hormone Receptor Deficiency Protects against Age-Related NLRP3 Inflammasome Activation and Immune SenescenceSpadaro O, Goldberg EL, Camell CD, Youm YH, Kopchick JJ, Nguyen KY, Bartke A, Sun LY, Dixit VD. Growth Hormone Receptor Deficiency Protects against Age-Related NLRP3 Inflammasome Activation and Immune Senescence. Cell Reports 2016, 14: 1571-1580. PMID: 26876170, PMCID: PMC5992590, DOI: 10.1016/j.celrep.2016.01.044.
- A Role of the Inflammasome in the Low Storage Capacity of the Abdominal Subcutaneous Adipose Tissue in Obese AdolescentsKursawe R, Dixit VD, Scherer PE, Santoro N, Narayan D, Gordillo R, Giannini C, Lopez X, Pierpont B, Nouws J, Shulman GI, Caprio S. A Role of the Inflammasome in the Low Storage Capacity of the Abdominal Subcutaneous Adipose Tissue in Obese Adolescents. Diabetes 2015, 65: 610-618. PMID: 26718495, PMCID: PMC4764142, DOI: 10.2337/db15-1478.
- Editorial: “Crowning” eosinophils in adipose tissue: does location matter?Goldberg EL, Dixit VD. Editorial: “Crowning” eosinophils in adipose tissue: does location matter? Journal Of Leukocyte Biology 2015, 98: 451-452. PMID: 26429777, DOI: 10.1189/jlb.3ce0415-178rr.
- Ketone body beta-hydroxy butyrate deactivates NLRP3 inflammasome in myeloid cells (CAM1P.153)Goldberg E, Youm Y, Nguyen K, Alnemri E, Dixit V. Ketone body beta-hydroxy butyrate deactivates NLRP3 inflammasome in myeloid cells (CAM1P.153). The Journal Of Immunology 2015, 194: 48.10-48.10. DOI: 10.4049/jimmunol.194.supp.48.10.
- NLRP3 inflammasome controls adipose tissue leukocytosis and inflammation during aging (INM6P.331)Camell C, Youm Y, Nguyen K, Ravussin A, Spadaro O, Dixit V. NLRP3 inflammasome controls adipose tissue leukocytosis and inflammation during aging (INM6P.331). The Journal Of Immunology 2015, 194: 193.5-193.5. DOI: 10.4049/jimmunol.194.supp.193.5.
- The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory diseaseYoum YH, Nguyen KY, Grant RW, Goldberg EL, Bodogai M, Kim D, D'Agostino D, Planavsky N, Lupfer C, Kanneganti TD, Kang S, Horvath TL, Fahmy TM, Crawford PA, Biragyn A, Alnemri E, Dixit VD. The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease. Nature Medicine 2015, 21: 263-269. PMID: 25686106, PMCID: PMC4352123, DOI: 10.1038/nm.3804.
- Adipose tissue as an immunological organGrant RW, Dixit VD. Adipose tissue as an immunological organ. Obesity 2015, 23: 512-518. PMID: 25612251, PMCID: PMC4340740, DOI: 10.1002/oby.21003.
- Metabolism and Aging: From Molecular Physiology to Systems Biology: 2015 meeting abstractsSharma L, Bai Y, Chou C, Bain J, Fillenbaum G, Pieper C, Cohen H, Huffman K, Kraus V, Camell C, Youm Y, Spadaro O, Ravussin A, Nguyen K, O'Neill L, Kaech S, Dixit V, Gribble K, Welch D, Hambright S, Munkácsy E, Khan M, Park J, Lane R, Bokov A, Link C, Rea S, Nizamutdinova I, Dusio G, Tobin R, Zawieja D, Newell-Rogers M, Santambrogio L, Gashev A, Westbrook R, Langdon J, Roy C, Yang H, Choudhury P, Xue Q, de Cabo R, Walston J, Schuld N, Ferrington D, Zhou Y, Liang H, Zhang N, Musi N, Rodriguez K, Khan M, Buffenstein R, Fisher A, Apple D, Fonseca R, dos Santos M, Mahesula S, Shu C, Kokovay E, Grimes K, Barefield D, Sadayappan S, Buffenstein R, Hussong S, Burbank R, Halloran J, Lin A, Soto V, Galvan V, Valentine J, Orr M, Liang H, Zhou Y, Musi N, Jahrling J, Derosa N, Lin A, Hussong S, Burbank R, Halloran J, Asmis R, Galvan V, Martinez P, Martinez V, Fernandez E, Strong R, Ahmed A, Alnabbat K, Smoczer C, Shah M, Ikeno Y, Cabelof D, Fonseca R, Mahesula S, Apple D, Raghunathan R, Dugan A, Cardona A, O'Connor J, Kokovay E, Manaye K, O'Neil J, Duttaroy A, Stout M, Jurk D, Jurczak M, Evans G, Zhu Y, Singh R, Lebrasseur N, Shulman G, von Zglinicki T, Tchkonia T, Kirkland J, Khan M, Fisher A, Mahoney R, Vasilakos G, Lei H, Matheny M, Yen F, Morales J, Barton E, Srikantan S, Deng Y, Luo A, Qin Y, Gao Q, Reddick R, Abdul-Ghani M, Dahia P, Seldeen K, Lasky G, Pang M, Leiker M, Troen B, van Skike C, Lin A, Burbank R, Halloran J, Cuvillier J, Hussong S, Jahrling J, Austad S, Fischer K, Galvan V, Clark N, Katolik A, Roberts K, Taylor A, Holloway S, Montemayor E, Stevens S, Fitzpatrick P, Damha M, Hart P, Singh R, Martinez V, Halloran J, Holstein D, Diaz V, Galvan V, Chaudhuri A, Gelfond J, Fernandez E, Lechleiter J, Strong R, Weiss R, Liu Y, Salmon A, Bitto A, Ito T, Le Texier N, Sutlief E, Tung H, Vizzini N, Snyder J, Treuting P, Kaeberlein M, Li G, McHardy S, Nicholson B, Strong R, Hart M, Garbarino V, Edwards M, Lozano R, Smolik C, Zhang W, Daws L, Gould G. Metabolism and Aging: From Molecular Physiology to Systems Biology: 2015 meeting abstracts. Pathobiology Of Aging & Age-related Diseases 2015, 5: 30765. PMID: 26725924, PMCID: PMC4698431, DOI: 10.3402/pba.v5.30765.
- Adipose Tissue Macrophages Promote Myelopoiesis and Monocytosis in ObesityNagareddy PR, Kraakman M, Masters SL, Stirzaker RA, Gorman DJ, Grant RW, Dragoljevic D, Hong ES, Abdel-Latif A, Smyth SS, Choi SH, Korner J, Bornfeldt KE, Fisher EA, Dixit VD, Tall AR, Goldberg IJ, Murphy AJ. Adipose Tissue Macrophages Promote Myelopoiesis and Monocytosis in Obesity. Cell Metabolism 2014, 19: 821-835. PMID: 24807222, PMCID: PMC4048939, DOI: 10.1016/j.cmet.2014.03.029.
- Inactivation of C/ebp Homologous Protein-driven Immune-Metabolic Interactions Exacerbate Obesity and Adipose Tissue Leukocytosis*Grant R, Nguyen KY, Ravussin A, Albarado D, Youm YH, Dixit VD. Inactivation of C/ebp Homologous Protein-driven Immune-Metabolic Interactions Exacerbate Obesity and Adipose Tissue Leukocytosis*. Journal Of Biological Chemistry 2014, 289: 14045-14055. PMID: 24662293, PMCID: PMC4022874, DOI: 10.1074/jbc.m113.545921.
- Growth hormone secretagogue (GHS) analogue, hexarelin stimulates GH from peripheral lymphocytes.Poppi L, Dixit VD, Baratta M, Giustina A, Tamanini C, Parvizi N. Growth hormone secretagogue (GHS) analogue, hexarelin stimulates GH from peripheral lymphocytes. Experimental And Clinical Endocrinology & Diabetes : Official Journal, German Society Of Endocrinology [and] German Diabetes Association 2002, 110: 343-7. PMID: 12397533, DOI: 10.1055/s-2002-34991.
- Plasma inhibin levels in relation to steroids and gonadotrophins during oestrous cycle in buffalo.Singh B, Dixit VD, Singh P, Georgie GC, Dixit VP. Plasma inhibin levels in relation to steroids and gonadotrophins during oestrous cycle in buffalo. Reproduction In Domestic Animals = Zuchthygiene 2001, 36: 163-7. PMID: 11555363.
- Effect of naloxone on the plasma levels of LH, FSH, prolactin and testosterone in Beetal bucks.Singh B, Dixit VD, Singh P, Georgie GC, Dixit VP. Effect of naloxone on the plasma levels of LH, FSH, prolactin and testosterone in Beetal bucks. Small Ruminant Research : The Journal Of The International Goat Association 2000, 37: 51-55. PMID: 10818303, DOI: 10.1016/s0921-4488(99)00129-7.
- Circadian and pulsatile variations in plasma levels of inhibin, FSH, LH and testosterone in adult Murrah buffalo bulls.Dixit VD, Singh B, Singh P, Georgie GC, Galhotra MM, Dixit VP. Circadian and pulsatile variations in plasma levels of inhibin, FSH, LH and testosterone in adult Murrah buffalo bulls. Theriogenology 1998, 50: 283-92. PMID: 10734496, DOI: 10.1016/s0093-691x(98)00136-8.